LANOSTEROL REGULATES ABNORMAL AMYLOID ACCUMULATION IN LECS THROUGH THE MEDIATION OF CHOLESTEROL PATHWAY METABOLISM

Lanosterol regulates abnormal amyloid accumulation in LECs through the mediation of cholesterol pathway metabolism

Age-related cataract (ARC) is the predominant cause of global blindness, linked to the progressive aging of the lens, oxidative stress, perturbed calcium homeostasis, hydration irregularities, and modifications in crystallin proteins.Currently, surgical intervention remains the bar drain board sole efficacious remedy, albeit carrying inherent risks

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Hybrid Simulation and Test of Vessel Traffic Systems on the Cloud

This paper presents a cloud-based hybrid simulation platform to test large-scale distributed system-of-systems for the management napoleon concealer and control of maritime traffic, the so-called vessel traffic systems (VTS).A VTS consists of multiple, heterogeneous, distributed, and interoperating systems, including radar, automatic identification

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Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction

Recombinant adeno-associated virus (rAAV) platforms hold promise for in vivo gene therapy but are undermined by the undesirable transduction of antigen presenting cells (APCs), which in turn can trigger host immunity towards rAAV-expressed transgene products.In light of recent adverse events in patients receiving high systemic AAV vector doses that

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